1760 – The Great Boston Fire of 1760 destroys 349 buildings.
1852 – Harriet Beecher Stowe’s Uncle Tom’s Cabin is published.
1854 – The Republican Party is organized in Ripon, Wisconsin.
1915 – Albert Einstein published his general theory of relativity.
1933 – Giuseppe Zangara is executed in Florida for fatally shooting Anton Cermak in an assassination attempt against President-Elect Franklin D. Roosevelt.
1985 – Libby Riddles becomes the first woman to win the Iditarod Trail Sled Dog Race.
2003 – In the early hours of the morning, the United States and three other countries begin military operations in Iraq.